theendopedia

Lornoxicam for endometriosis

Pharmaceutical

Last reviewed

Lornoxicam is a prescription anti-inflammatory painkiller from the same family as piroxicam and meloxicam. No studies have tested it in people with endometriosis, and we found no endo community discussion of it in any language. One small trial in ordinary period pain found it worked about as well as ibuprofen, and it has a solid track record for pain after gynaecological surgery. What we know about it for endo is borrowed from NSAIDs as a group.

Research status

Early Stage

Endo-specific

No

Community signal

Limited data

How does Lornoxicam work?

Lornoxicam blocks both forms of the cyclooxygenase enzyme (COX-1 and COX-2), which the body uses to make prostaglandins. Prostaglandins drive uterine cramping, pain signalling and local inflammation, and endometriosis lesions produce them in excess. Lowering prostaglandin levels can ease period pain and some of the inflammatory pain linked to endo. Unlike older drugs in its class, lornoxicam leaves the body quickly (a half-life of roughly 3 to 5 hours), so it acts more like a short-acting painkiller than a long-acting one. Like other NSAIDs, it treats symptoms and is not thought to shrink or remove endometriosis lesions.

What does the research show about Lornoxicam for endometriosis?

Below are studies linked to this intervention in our database, with design, quality, and outcomes summarised for quick scanning. Endo-specific evidence in this entry: No.

14 studies

  • Efficacy of preemptive analgesia treatments for the management of postoperative pain: a network meta-analysis

    Xuan C et al. · 2022

    Meta-analysisNot endo-specificQuality: High

    Across 188 surgical trials, lornoxicam given before surgery had the largest single reduction in pain at 6 hours of the 19 regimens compared.

    View publication

  • Comparison between Lornoxicam and Paracetamol for Pain Management after Dilation and Curettage for Abortion

    Mustafa-Mikhail S et al. · 2017

    RCTn=80Not endo-specificQuality: Medium

    After dilation and curettage, IV lornoxicam 20 mg gave lower pain scores than IV paracetamol from 30 minutes until discharge.

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  • Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study

    Patel JC et al. · 2015

    RCTn=57Not endo-specificQuality: Medium

    In young women with period pain, lornoxicam 8 mg twice daily relieved pain about as well as ibuprofen 400 mg, with similar side effects. It is the only lornoxicam trial in menstrual pain.

    View publication

  • Nonsteroidal anti-inflammatory drugs for dysmenorrhoea

    Marjoribanks J et al. · 2015

    Systematic reviewNot endo-specificQuality: High

    Across 80 trials, NSAIDs clearly beat placebo for period pain but caused more side effects, and no single NSAID stood out. A lornoxicam trial was listed as awaiting assessment and was not analysed.

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  • Comparison between the combination of gabapentin, ketamine, lornoxicam, and local ropivacaine and each of these drugs alone for pain after laparoscopic cholecystectomy: a randomized trial

    Kotsovolis G et al. · 2015

    RCTn=148Not endo-specificQuality: High

    After laparoscopic surgery, lornoxicam alone roughly halved 24-hour morphine use versus placebo and worked as well as a four-drug combination.

    View publication

What do people in online endo communities say about Lornoxicam?

Community signals are indicative only — they reflect informal conversation in endometriosis-focused spaces. People posting may or may not have a formal diagnosis; this is not a substitute for clinical evidence or care.

Non-English forums

Limited data · 1 mentions

  • “I take it for most periods; one tablet a day usually does it, sometimes two days. But it affects clotting, so I would not take it often or in large amounts during a period. [RU, period pain]”

    — Non-English forums

  • “A really strong painkiller, but if you have ever had stomach problems be careful, it can bring them back. [TR, general use]”

    — Non-English forums

  • “The injections did not really help, and it is expensive. [RU, back pain]”

    — Non-English forums

How is Lornoxicam typically used?

Practical notes

Prescription-only. It is sold in parts of Europe, Russia and neighbouring countries, Turkey, the Middle East, South and East Asia and Latin America. It is not marketed in the US and was withdrawn in Switzerland in 2020. In Turkey, Xefo Rapid is labelled for menstrual pain among other uses; in most other markets it is labelled for arthritis, acute pain and post-surgical pain. The usual adult dose for acute pain is 8 mg two or three times a day, up to 16 mg a day; the dysmenorrhoea trial used 8 mg twice daily for up to three days per cycle. It carries the standard NSAID cautions: stomach upset, ulcers and bleeding (a stomach-protecting drug is sometimes co-prescribed); kidney strain; raised blood pressure and cardiovascular risk with longer use; and avoidance in the third trimester of pregnancy, in severe heart, liver or kidney disease, and in people whose asthma is triggered by aspirin or NSAIDs. It reduces platelet clumping, which can lengthen bleeding time and may make heavy periods heavier. It interacts with anticoagulants, other NSAIDs including aspirin, lithium, methotrexate, digoxin, some diabetes drugs (glibenclamide) and blood-pressure medicines. People with the CYP2C9*3 gene variant clear it more slowly.

What should you know before trying Lornoxicam?

None specific to lornoxicam beyond NSAID class warnings. One animal study found it impaired the healing of surgical bowel joins, which may matter around bowel endometriosis surgery. That is animal-only evidence, not a human signal.

Related interventions

Other interventions in our database that target similar symptoms or fall under the same category as Lornoxicam.

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